There are a few odd problems with the September Microsoft patches, but they’re relatively sporadic and reasonably-well understood. That makes it’s a good time to get the outstanding updates installed, though you should avoid the “optional” patches.
I’m still not ready to put Windows 10 version 2004 on my main machines. The “E Week” optional, non-security patch, KB 4577063, fixes two well-known bugs and many dozens of lesser bugs (none of which were officially documented, by the way) in the latest released version of Windows 10. @mikemeinz has hit several replicated bugs in Win10 version 2004, and bug reports continue to hit my inbox.